Gene Variations May Connect Endometriosis and Ovarian Cancer


Researchers studying variations in the HNF1B gene (a gene previously linked to other diseases like liver dysfunction, endometrial cancer and prostate cancer) may have found a link between endometriosis and the development of ovarian cancer, according to the results of the study.

The study included 385 endometriosis patients and 484 healthy participants who provided blood samples for genetic analysis.  The analysis showed that a variation in the HNF1B gene was associated with endometriosis, providing a link between this disease and ovarian cancer. None of the other variations tested were associated with a risk of endometriosis.

Endometriosis occurs when the lining of the uterus grows outside the uterus. Previous studies have suggested the condition is a risk factor for ovarian cancer.

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